Mouse Dickkopf-related Protein 1, DKK1 ELISA Kit, 96T Human Genome Knockout Libraries Mutations in CYCS are associated

Mutations in CYCS are associated with autosomal dominant nonsyndromic thrombocytopenia

and may contribute to the multidrug resistance phenomenon

an arrangement which is thought to have evolved by a series of gene duplications

Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes

Alternative splicing of this gene results in two transcript variants encoding distinct isoforms

Mouse Dickkopf-related Protein 1, DKK1 ELISA Kit, 96T Human Genome Knockout Libraries Mutations in CYCS are associatedAntagonizes canonical Wnt signaling by inhibiting LRP5 6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5 6 (PubMed: 18524778). Inhibits the pro apoptotic function of KREMEN1 in a Wnt independent manner, and has anti apoptotic activity (PubMed: 26206087). Plays a role in limb development; attenuates Wnt signaling in the developing limb to allow normal limb patterning