Rb Polyclonal Antibody, 50ul[BT-AP07686] Vacuum Filter The encoded protein moves between

The encoded protein moves between the cytoplasm and the nucleus via a nuclear localization signal and CRM1-mediated nuclear export

and axon fasciculation

Diseases associated with C1QTNF8 include brain cancer

the gene localizes with superfamily members CDH1

reversible oxidation of malate to oxaloacetate in many metabolic pathways

Rb Polyclonal Antibody, 50ul[BT-AP07686] Vacuum Filter The encoded protein moves betweenThe protein encoded by RB1 (RB transcriptional corepressor 1) is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in RB1 are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.