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Raf-1 Polyclonal Antibody, 100ul[BT-AP13531] Drug Development and Evaluation This protein may also regulate

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Raf-1 Polyclonal Antibody, 100ul[BT-AP13531] Drug Development and Evaluation This protein may also regulateThis gene is the cellular homolog of viral raf gene (v raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine threonine specific protein kinases, ERK1 and ERK2.

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Description

This protein may also regulate inflammation and innate immunity

The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity

Specific isoforms bind to alpha-dystroglycan and to alpha-latroxin

This gene has been implicated in the formation of beta-amyloid and atherosclerotic plaques by controlling the equilibrium between free cholesterol and cytoplasmic cholesteryl esters

angiopoietin-2

Raf-1 Polyclonal Antibody, 100ul[BT-AP13531] Drug Development and Evaluation This protein may also regulateThis gene is the cellular homolog of viral raf gene (v raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine threonine specific protein kinases, ERK1 and ERK2.

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