FoxO1/3/4(Phospho Thr24/32) Polyclonal Antibody, 100ul Capsule Filter NCOA5 (nuclear receptor coactivator 5)

NCOA5 (nuclear receptor coactivator 5) encodes a coregulator for the alpha and beta estrogen receptors and the orphan nuclear receptor NR1D2

Mutations in CSH1 result in placental lactogen deficiency and Silver-Russell syndrome

The encoded protein interacts with the C-terminal domain of ezrin| an ERM protein| and may play a role in cell adhesion and migration

The encoded protein is also a putative tumor suppressor protein| and decreased expression of this gene is associated with several malignancies including breast cancer and adult T-cell leukemia

This gene is located in a chromosomal region that was genetically linked to Parkinson disease type 11

FoxO1/3/4(Phospho Thr24/32) Polyclonal Antibody, 100ul Capsule Filter NCOA5 (nuclear receptor coactivator 5)This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. The specific function of this gene has not yet been determined; however, it may play a role in myogenic growth and differentiation. Translocation of this gene with PAX3 has been associated with alveolar rhabdomyosarcoma.