HSF4 Polyclonal Antibody, 20ul Rotator The myotrophin protein is associated

The myotrophin protein is associated with cardiac hypertrophy

beta and gamma

It is an adaptor protein localized in the nucleus

Multiple alternatively spliced transcript variants encoding the same protein have been found

It is also expressed in T lymphocytes and may function to inhibit interleukin-2 transcription by disrupting calcineurin-dependent dephosphorylation of NFAT

HSF4 Polyclonal Antibody, 20ul Rotator The myotrophin protein is associatedHeat shock transcription factors (HSFs) activate heat shock response genes under conditions of heat or other stresses. HSF4 lacks the carboxyl terminal hydrophobic repeat which is shared among all vertebrate HSFs and has been suggested to be involved in the negative regulation of DNA binding activity. Two alternatively spliced transcripts encoding distinct isoforms and possessing different transcriptional activity have been described.