SIRT2 Polyclonal Antibody, 20ul Enzyme Activity Assays Mutations in the promoter region

Mutations in the promoter region of this gene lead to a diminished response to antileukotriene drugs used in the treatment of asthma and may also be associated with atherosclerosis and several cancers

The low affinity form is a monomer of the alpha subunit and is not involved in signal transduction

where it constitutes the regulatory subunit

Mutations in CEP57 cause mosaic variegated aneuploidy syndrome

The extracellular region possesses a lengthy Pro‑rich region (aa 55‑200)

SIRT2 Polyclonal Antibody, 20ul Enzyme Activity Assays Mutations in the promoter regionSIRT2 encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular