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Ob-R Polyclonal Antibody, 50ul[BT-AP06324] Bio-Reaction Tube Although the Y-linked genes are

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Ob-R Polyclonal Antibody, 50ul[BT-AP06324] Bio-Reaction Tube Although the Y-linked genes areThe protein encoded by LEPR belongs to the gp130 family of cytokine receptors that are known to stimulate gene transcription via activation of cytosolic STAT proteins. This protein is a receptor for leptin (an adipocyte specific hormone that regulates body weight), and is involved in the regulation of fat metabolism, as well as in a novel hematopoietic pathway that is required for normal lymphopoiesis. Mutations in this gene have been associated with

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Description

Although the Y-linked genes are testis-specific

The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity

The protein encoded by this gene is similar in sequence to tubulointerstitial nephritis antigen| a secreted glycoprotein that is recognized by antibodies in some types of immune-related tubulointerstitial nephritis

AR contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein

Also cleaves collagens of types VII and X

Ob-R Polyclonal Antibody, 50ul[BT-AP06324] Bio-Reaction Tube Although the Y-linked genes areThe protein encoded by LEPR belongs to the gp130 family of cytokine receptors that are known to stimulate gene transcription via activation of cytosolic STAT proteins. This protein is a receptor for leptin (an adipocyte specific hormone that regulates body weight), and is involved in the regulation of fat metabolism, as well as in a novel hematopoietic pathway that is required for normal lymphopoiesis. Mutations in this gene have been associated with

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