PDE1A Polyclonal Antibody, 100ul Isothermal Amplification The protein kinase localizes to

The protein kinase localizes to the Golgi apparatus and is specifically activated by binding to the Golgi matrix protein GM130

secreted protein containing a C-terminal fibrinogen domain

GO annotations related to this gene include ligase activity and ubiquitin protein ligase activity

The protein encoded by this gene is a type III enzyme that is not inhibited by adenosine

subunit:Interacts (via SH3 domain) with COL7A1

PDE1A Polyclonal Antibody, 100ul Isothermal Amplification The protein kinase localizes toCyclic nucleotide phosphodiesterases (PDEs) play a role in signal transduction by regulating intracellular cyclic nucleotide concentrations through hydrolysis of cAMP and or cGMP to their respective nucleoside 5 prime monophosphates. Members of the PDE1 family, such as PDE1A, are Ca(2+) calmodulin (see CALM1; MIM 114180) dependent PDEs (CaM PDEs) that are activated by calmodulin in the presence of Ca(2+) (Michibata et al., 2001