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CD6 Polyclonal Antibody, 50ul[BT-AP01719] Monoclonal Antibody Preparation Mutations of this gene have

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CD6 Polyclonal Antibody, 50ul[BT-AP01719] Monoclonal Antibody Preparation Mutations of this gene haveThe protein encoded by CFLAR (CASP8 and FADD like apoptosis regulator) is a regulator of apoptosis and is structurally similar to caspase 8. However, the encoded protein lacks caspase activity and appears to be itself cleaved into two peptides by caspase 8. Several transcript variants encoding different isoforms have been found for CFLAR, and partial evidence for several more variants exists.

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Description

Mutations of this gene have been associated with branchiootorenal dysplasia syndrome

IL26 (interleukin 26) was identified by its overexpression specifically in herpesvirus samimiri-transformed T cells

stimulates dissociation of TOP1 from DNA after cleavage and enhances its jumping between separate DNA helices

suggesting that it functions as a transcription factor

myopic chorioretinal atrophy

CD6 Polyclonal Antibody, 50ul[BT-AP01719] Monoclonal Antibody Preparation Mutations of this gene haveThe protein encoded by CFLAR (CASP8 and FADD like apoptosis regulator) is a regulator of apoptosis and is structurally similar to caspase 8. However, the encoded protein lacks caspase activity and appears to be itself cleaved into two peptides by caspase 8. Several transcript variants encoding different isoforms have been found for CFLAR, and partial evidence for several more variants exists.

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