Mre11(Phospho-Ser676) Rabbit Polyclonal Antibody, 50ul Recombinant Ab Production Defects in VCL are the

Defects in VCL are the cause of cardiomyopathy dilated type 1W

a single pass transmembrane region

It may play a role in signal transduction cascades in terminally differentiated cells

The RS domain is required for the interaction with the phosphorylated C-terminal domain of RNA polymerase II

Mutation in this gene was also observed in individuals with metacarpal 4-5 fusion

Mre11(Phospho-Ser676) Rabbit Polyclonal Antibody, 50ul Recombinant Ab Production Defects in VCL are theThis gene encodes a nuclear protein involved in homologous recombination telomere length maintenance and DNA double strand break repair. By itself the protein has 3' to 5' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog; this complex is required for nonhomologous joining of DNA ends and possesses increased single stranded DNA endonuclease and 3' to 5' exonuclease activities. In conjunction with a DNA