Ref-1 Polyclonal Antibody, 20ul[BT-AP07734] Glassware Sets Two alternatively spliced transcript variants

Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported

SLC16A2 is subject to X-chromosome inactivation

Embryos of transgenic mice in which both alleles of the gamma 1 chain gene were inactivated by homologous recombination

An important paralog of this gene is RTCA

Mutations in this gene cause X-linked severe combined immunodeficiency (XSCID)

Ref-1 Polyclonal Antibody, 20ul[BT-AP07734] Glassware Sets Two alternatively spliced transcript variantsApurinic apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. APEX1 encodes the major AP endonuclease in human cells.