PPX Monoclonal Antibody, 100ul Centrifuges E3 ubiquitin-protein ligase Mdm2 can

E3 ubiquitin-protein ligase Mdm2 can promote tumor formation by targeting tumor suppressor proteins

Knockout studies of the mouse homolog suggest RAD50 is essential for cell growth and viability

Serves as receptor for nuclear localization signals (NLS) in cargo substrates

Human proteins MECP2| MBD1| MBD2| MBD3| and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD)

RDX has been localized by fluorescence in situ hybridization to 11q23

PPX Monoclonal Antibody, 100ul Centrifuges E3 ubiquitin-protein ligase Mdm2 cancatalytic activity: A phosphoprotein + H(2)O = a protein + phosphate.,cofactor: Binds 1 iron ion per subunit.,cofactor: Binds 1 manganese ion per subunit.,function: Protein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, tumor necrosis factor (TNF) alpha signaling, activation of c Jun N terminal kinase MAPK8, regulation of histone acetylation, DNA damage