SRA1 Monoclonal Antibody, 50ul[BT-MCA1156] Polyclonal Antibodies GTP cyclohydrolase I feedback regulatory

GTP cyclohydrolase I feedback regulatory protein binds to and mediates tetrahydrobiopterin inhibition of GTP cyclohydrolase I

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Isoforms that are expressed in muscle and ubiquitously expressed isoforms localize to the cytoplasm and nucleus and activate a caspase-independent apoptotic process

It was initially thought to be the 70kD component of a nucleosome remodeling deacetylase complex

A similar protein in mammals and other organisms is a component of the RNA-induced silencing complex (RISC)

SRA1 Monoclonal Antibody, 50ul[BT-MCA1156] Polyclonal Antibodies GTP cyclohydrolase I feedback regulatoryBoth long non coding and protein coding RNAs are transcribed from this gene, and they represent alternatively spliced transcript variants. This gene was initially defined as a non coding RNA, which is a coactivator for several nuclear receptors (NRs) and is associated with breast cancer. It has now been found that this gene is involved in the regulation of many NR and non NR activities, including metabolism, adipogenesis and chromatin organization.