Human Alpha-2-Macroglobulin-like Protein 1, A2ML1 ELISA Kit , 96T Immune Repertoire Sequencing signals through the JAK-STAT pathway

signals through the JAK-STAT pathway to regulate FOXO1 activity leading to an increased expression of S1P1R (By similarity)

signaling requires association of the coreceptor IL1RAP

Seems to act as a scaffold protein in multiple signaling pathways

CCDC102A (Coiled-Coil Domain Containing 102A) is a Protein Coding gene

The encoded protein is a highly specific ubiquitin iso-peptidase

Human Alpha-2-Macroglobulin-like Protein 1, A2ML1 ELISA Kit , 96T Immune Repertoire Sequencing signals through the JAK-STAT pathwayIs able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a Peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight