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FA11 Rabbit Polyclonal Antibody, 50ul[BT-AP09939] Peptide Synthesis The encoded protein is a

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FA11 Rabbit Polyclonal Antibody, 50ul[BT-AP09939] Peptide Synthesis The encoded protein is aThis gene encodes coagulation factor XI of the blood coagulation cascade. This protein is present in plasma as a zymogen which is a unique plasma coagulation enzyme because it exists as a homodimer consisting of two identical polypeptide chains linked by disulfide bonds. During activation of the plasma factor XI an internal peptide bond is cleaved by factor XIIa (or XII) in each of the two chains resulting in activated factor XIa a serine protease

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Description

The encoded protein is a cell surface glycoprotein that is known to complex with integrins

The protease consists of two heptameric rings of the CLPP catalytic subunit sandwiched between two hexameric rings of the chaperone subunit encoded by this gene

Has over 50-fold higher inhibitory activity when phosphorylated

as tumors with BRCA2 mutations generally exhibit loss of heterozygosity (LOH) of the wild-type allele

This enzyme has an important role in regulating amino acid-induced insulin secretion

FA11 Rabbit Polyclonal Antibody, 50ul[BT-AP09939] Peptide Synthesis The encoded protein is aThis gene encodes coagulation factor XI of the blood coagulation cascade. This protein is present in plasma as a zymogen which is a unique plasma coagulation enzyme because it exists as a homodimer consisting of two identical polypeptide chains linked by disulfide bonds. During activation of the plasma factor XI an internal peptide bond is cleaved by factor XIIa (or XII) in each of the two chains resulting in activated factor XIa a serine protease

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