Rb Monoclonal Antibody, 50ul Bacterial Expression Efficiently prepare your DNA or

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Naturally occurring read-through transcription occurs between the upstream gene NPHP3 (nephronophthisis 3 (adolescent)) and this gene

The precise function of this protein is unknown

and they are activated by binding GTP and inactivated by conversion of GTP to GDP by their intrinsic GTPase activity

Mutations in this gene have been associated with pseudohypoaldosteronism type II and hereditary sensory neuropathy type II

Rb Monoclonal Antibody, 50ul Bacterial Expression Efficiently prepare your DNA orThe protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.