Rat Insulin-like Growth Factors 1 Receptor, IGF-1R ELISA Kit, 96T DNA Fragments The human engrailed homologs 1
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Rat Insulin-like Growth Factors 1 Receptor, IGF-1R ELISA Kit, 96T DNA Fragments The human engrailed homologs 1Receptor tyrosine kinase which mediates actions of Insulin like growth factor 1 (IGF1). Binds IGF1 with high affinity and IGF2 and insulin (INS) with a lower affinity. The activated IGF1R is involved in cell growth and survival control. IGF1R is crucial for tumor transformation and survival of malignant cell. Ligand binding activates the receptor kinase, leading to receptor autophosphorylation, and tyrosines phosphorylation of multiple substrates,
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