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Many common biologic treatments for PsA work by blocking TNF-alpha, IL-17, or IL-23 to reduce inflammation

Crosstalk between classical and non-classical inflammasome pathways, partly mediated by caspase-8, may further maintain IL-1 production and contribute to progressive tophus growth

75 SFN has been previously shown to have protective effects against oxidative stress-damaged tissues, such as the brain, heart, pancreas and kidney