SH3K1 Polyclonal Antibody, 50ul Pipette Filler In functional expression studies

In functional expression studies

is ubiquitously expressed and localized in the cytoplasm

There are pseudogenes for this gene on chromosomes 1 and 15

Phosphorylation on Ser-362 and Ser-374 primes further phosphorylations on Thr-325 and Thr-331 through promoting docking of MAPK to the DEF domain

Two transcript variants resulting from alternative splicing of the 3' terminal exon

SH3K1 Polyclonal Antibody, 50ul Pipette Filler In functional expression studiesThis gene encodes an adapter protein that contains three N terminal Src homology domains, a proline rich region and a C terminal coiled coil domain. The encoded protein facilitates protein protein interactions and has been implicated in numerous cellular processes including apoptosis, cytoskeletal rearrangement, cell adhesion and in the regulation of clathrin dependent endocytosis. Alternate splicing results in multiple transcript variants.