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Korkushko OV, Khavinson VK, Shatilo VB, et al

This pattern of Delta sleep inducing peptide is particularly influential during slow-wave sleep (SWS) and rapid eye movement (REM) sleep, the phases when we dream and rejuvenate our minds (Kastin & Akerstrom, 2003)

By contrast, potentiation by the dihydroxysterol does not require the ligand-binding domain but instead requires a membrane proximal portion of the carboxy terminal domain of the NMDAR, consistent with an intracellularly directed site for receptor activation

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