LDK378 - CAS# 1032900-25-6 rary of Histone Methyltransferase Odanacatib

Odanacatib

is an NMDA glutamate receptor antagonist

Smiles: CC1=CC(=CC=C1)[C@@H]1CC[C@@H](CC1)N1CCN(CC1)C1=CN=CC=C1

CK-1827452 demonstrates good PK parameters in both rats (Sprague−Dawley) and dogs (Beagle) with clearances of 22 and 7

is a topically administered metabolic precursor of protoporphyrin IX

LDK378 - CAS# 1032900-25-6 rary of Histone Methyltransferase OdanacatibCeritinib, also known as LDK378, is a selective inhibitor of ALK1, a target found in metastatic non small cell lung cancer (NSCLC). In Phase I trials, LDK378 showed a marked clinical response in 78 patients with anaplastic lymphoma kinase positive (ALK+) metastatic non small cell lung cancer (NSCLC) who had progressed during or after crizotinib therapy or had not been previously treated with crizotinib. LDK378 blocks the ALK protein and stops it