GK921 Catalog No.:M8587-2 VH-298 is a potent VHL

VH-298 is a potent VHL inhibitor that stabilizes HIF-α and elicits a hypoxic response via a different mechanism

Molecular Weight: 460

AB928 shows rescue of these gene expression changes

InChi: InChI=1S/C32H46N4O6S/c1-21-28(43-20-34-21)23-15-13-22(14-16-23)18-33-30(41)25-17-24(37)19-36(25)31(42)29(32(2

27-epoxypyrido[2

GK921 Catalog No.:M8587-2 VH-298 is a potent VHLGK921 is a transglutaminase 2 (TGase 2) inhibitor. GK921 showed cytotoxicity to RCC (average GI50 in eight RCC cell lines: 0. 905 M). A single treatment with GK921 almost completely reduced tumor growth by stabilizing p53 in the ACHN and CAKI 1 preclinical xenograft tumor models. TGase 2 inhibitor GK921 abrogates RCC growth in xenograft tumor models, suggesting the possibility of a new therapeutic approach to RCC. Product information CAS Number: