EPZ015666 (GSK3235025) - PRMT5 Inhibitor. CAS# 1616391-65-1 size:10 mg solid AC-55541 was well absorbed when

AC-55541 was well absorbed when administered intraperitoneally to rats

DASA-58 (40 μM) treated cells are injected into male SCID-bg/bg mice bearing PC3 tumors by IV

correlates with CK2α mRNA and protein levels but not the CK2α' catalytic subunit

increased blood hemoglobin and hematocrit

(Z)-4-Hydroxytamoxifen: a previously characterised as an Estrogen Receptor antagonist and now found to improve genome-editing specificity

EPZ015666 (GSK3235025) - PRMT5 Inhibitor. CAS# 1616391-65-1 size:10 mg solid AC-55541 was well absorbed whenEPZ015666, also known as GSK3235025, CAS No. 1616391 65 1, is a potent and selective and orally active PRMT5 inhibitor with a half maximal inhibitory concentration (IC50) of 22 nM and broad selectivity against a panel of other histone methyltransferases. Treatment of MCL cell lines with EPZ015666 led to inhibition of SmD3 methylation and cell death, with IC50 values in the nanomolar range. Oral dosing with EPZ015666 demonstrated dose dependent