ML-180 297 Identification of a Potent Tryptophan-Based

Identification of a Potent Tryptophan-Based TRPM8 Antagonist With in Vivo Analgesic Activity

the effect of B106 is greater than rottlerin (10-fold) in SBcl2 cells

Epub 2016 Mar 10

suggesting that PF-06282999 is equally distributed into plasma and red blood cells[1]

Brain Behav Immun

ML-180 297 Identification of a Potent Tryptophan-BasedML 180 (SR1848) is a potent orphan nuclear receptor liver receptor homolog 1 (LRH 1; NR5A2) inverse agonist with an IC50 of 3. 7 M. ML 180 is inactive for steroidogenic factor 1 (SF 1; NR5A1; IC50>10 M). ML 180 has the potential for LRH 1 dependent cancers . Product information CAS Number: 863588 32 3 Molecular Weight: 388. 89 Formula: C20H25ClN4O2 Chemical Name: 6 [4 (3 chlorophenyl)piperazin 1 yl] 3 cyclohexyl 1H pyrimidine 2,4 dione Smiles: