PFI-4 - BRPF1 Bromodomain Inhibitor. CAS# 900305-37-5 0020 HG-10-102-01 is the first compound

HG-10-102-01 is the first compound reported to be capable of inhibiting Ser910 and Ser935 phosphorylation in mouse brain following intraperitoneal delivery of doses as low as 50 mg/kg

but not to the extent of glucocorticoid inhibition

Molecular Weight: 381

J Am Chem Soc

Small-Molecule Inducer of β Cell Proliferation Identified by High-Throughput Screening

PFI-4 - BRPF1 Bromodomain Inhibitor. CAS# 900305-37-5 0020 HG-10-102-01 is the first compoundPFI 4, CAS No. 900305 37 5, is a potent, selective and cell permeable BRPF1 bromodomain inhibitor. It binds to BRPF1B with a Kd of 13 nM (ITC). It has general >100 fold selectivity against other bromodomains including BRPF2, BRPF3 and BRD4. It reduces recovery time in triple BRD cell construct in FRAP and is potent in cells with IC50 250 nM, while showing no effect on BRPF1A. Product information CAS Number: 900305 37 5 Molecular Weight: 380. 44