Lonafarnib - CAS# 193275-84-2 702 CAS Number: 511-28-4

CAS Number: 511-28-4

is potentially for the treatment of malaria

2014 May-Jun

reduces Phospholipase A2 (PLA2) activity and sPLA2-IIA mRNA expression and mitigates LPS-induced lung injury by increasing increased Clara cell secretory protein (CCSP) expression

Metformin (500 μM) or AICAR strongly suppresses SREBP-1 mRNA expression in rat hepatocytes

Lonafarnib - CAS# 193275-84-2 702 CAS Number: 511-28-4Lonafarnib is a farnesyl transferase inhibitor. Structurely, it is also a synthetic tricyclic derivative of carboxamide with antineoplastic properties. Lonarfanib binds to and inhibits farnesyl transferase, an enzyme involved in the post translational modification and activation of Ras proteins. Ras proteins participate in numerous signalling pathways (proliferation, cytoskeletal organization), and play an important role in oncogenesis. Mutated ras