PF06447475 - CAS# 1527473-33-1 0197 highly potent and selective BMP

highly potent and selective BMP pathway inhibitor by inhibiting BMP type I receptors ALK2 (IC50=5 nM) and ALK3 (IC50=30 nM)

Effect of Pritelivir Compared With Valacyclovir on Genital HSV-2 Shedding in Patients With Frequent Recurrences: A Randomized Clinical Trial

Cardiac ion channel current modulation by the CFTR inhibitor GlyH-101

0% (v/v) Tween-80 in 0

Org Biomol Chem

PF06447475 - CAS# 1527473-33-1 0197 highly potent and selective BMPPF06447475, CAS No. 1527473 33 1, is a highly potent, selective, brain penetrant, and in vivo active LRRK2 kinase inhibitor. Leucine rich repeat kinase 2 (LRRK2) has been genetically linked to Parkinson's disease (PD) by genome wide association studies (GWAS). The most common LRRK2 mutation, G2019S, which is relatively rare in the total population, gives rise to increased kinase activity. As such, LRRK2 kinase inhibitors are potentially useful in the