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DDR1-IN-1 - CAS# 1449685-96-4 size:10mg solid KGN also shows chondro-protective effects

DDR1-IN-1 - CAS# 1449685-96-4 size:10mg solid KGN also shows chondro-protective effects

Name: DDR1-IN-1 - CAS# 1449685-96-4 size:10mg solid KGN also shows chondro-protective effects
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DDR1-IN-1 - CAS# 1449685-96-4 size:10mg solid KGN also shows chondro-protective effectsDDR1 IN 1, CAS No. 1449685 96 4, is a potent and selective DDR1 inhibitor with IC50 of 105 nM, about 3 fold selectivity over DDR2. DDR1 IN 1 binds to DDR1 in the 'DFG out' conformation and inhibits DDR1 autophosphorylation in cells at submicromolar concentrations with good selectivity as assessed against a panel of 451 kinases measured. DDR1 IN 1 provides a useful pharmacological probe for DDR1 dependent signal transduction. The DDR1 receptor tyrosine

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Description

KGN also shows chondro-protective effects in vitro

Formula: C24H20N4O

2015 Jul 17

The expression

Smiles: CC#CC(=O)N1CCC[C@H]1C1=NC(C2C=CC(=CC=2)C(=O)NC2=CC=CC=N2)=C2C(N)=NC=CN12

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