CID-2011756 - CAS# 638156-11-3 329 21 μM) isoforms of the

21 μM) isoforms of the enzyme

Chemical Name: (S)-N-(bis(4-fluorophenyl)methyl)-1-(2-(2-ethyl-2-isobutyramidobutanamido)-5-guanidinopentanamido)cyclopentanecarboxamide

Palsson-McDermott EM

InChiKey: WRUWGLUCNBMGPS-UHFFFAOYSA-N

It inhibits phosphorylation of the mTORC1 substrates 4E-BP1 and S6K1 as well as the mTORC2 substrate AKT in diverse cancer models in vitro and in vivo

CID-2011756 - CAS# 638156-11-3 329 21 μM) isoforms of theCID 2011756, CAS No. 638156 11 3, is a cell active ATP competitive and specific PKD1 inhibitor that inhibits phorbol ester induced endogenous PKD1 activation in LNCaP prostate cancer cells. IC50 Value: 100. 7 uM (cellular inhibition of phospho Ser916 PKD1 activity) [1] Target: PKD CID 2011756, has pan PKD inhibitory effects (PKD2 IC50 = 0. 60. 1 uM; PKD3 IC50 = 0. 70. 2 uM) with similar, albeit not identical, potencies which may be expected for an ATP