PROTAC Bcl2 degrader-1 agonist Vesnarinone

Vesnarinone

330(2):430-9

InChi: InChI=1S/C18H11BrN2O2/c19-12-6-7-17(22)14(8-12)16-9-13(11-4-2-1-3-5-11)15(10-20)18(23)21-16/h1-9

32)33)34-18-26-29-30-27(35-23-7-3-4-8-23)31(26)21-6-5-15-28-17-21/h5-6

PubMed PMID: 23030482

PROTAC Bcl2 degrader-1 agonist VesnarinonePROTAC Bcl2 degrader 1 (Compound C5) is a PROTAC, which potently and selectively induces the degradation of Bcl 2 (IC50, 4. 94 M; DC50, 3. 0 M) and Mcl 1 (IC50, 11. 81 M) by introducing the E3 ligase cereblon (CRBN) binding ligand pomalidomide to Mcl 1 Bcl 2 dual inhibitor Nap 1. Product information CAS Number: 2378801 85 3 Molecular Weight: 941. 84 Formula: C45H45BrN6O10S Chemical Name: N' (2 {8 [(4 bromophenyl)sulfanyl] 2, 4 dioxo 3 azatricyclo[7.