ADC Toxin Monomethyl auristatin F (MMAF) - CAS# 745017-94-1 Catalog No.:T60002-10S is a selective and potent

is a selective and potent dual inhibitor of mTORC1 and mTORC2 with IC50 of 22 nM and 65 nM

ACY-1215 was used at 1 µM final concentration in vitro and in cellular assays

activates human GPR84 in the presence of Gqi5 chimera in HEK293 cells with an EC50 of 105 nM in the PI assay

It induces a G2/M cell cycle arrest by interfering with the normal development of the mitotic spindle and causing collapsed spindle apparatus and multiple nucleation centres

2 mg solid each for the following compounds:

ADC Toxin Monomethyl auristatin F (MMAF) - CAS# 745017-94-1 Catalog No.:T60002-10S is a selective and potentMMAF (Monomethylauristatin F) , CAS No. 745017 94 1, is a potent tubulin polymerization inhibitor and is used as a antitumor agent. MMAF (Monomethylauristatin F) is widely used as a cytotoxic component of antibody drug conjugates (ADCs) such as vorsetuzumab mafodotin and SGN CD19A. Product information CAS Number: 745017 94 1 Molecular Weight: 731. 96 Formula: C39H65N5O8 Chemical Name: (S) 2 ((2R,3R) 3 ((S) 1 ((3R,4S,5S) 4 ((S) N,3 dimethyl 2 ((S) 3