GS143 - IkappaB Ubiquitination Inhibitor. CAS# 916232-21-8 187 Remodelin is a useful chemical

Remodelin is a useful chemical tool to study how NAT10 affects nuclear architecture and suggest alternative strategies for treating laminopathies and aging

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Filippakopoulos

Aragon-Ching JB

in the pore of the cystic fibrosis transmembrane conductance regulator

GS143 - IkappaB Ubiquitination Inhibitor. CAS# 916232-21-8 187 Remodelin is a useful chemicalGS143, CAS No. 916232 21 8, is selective TrCP1 ligase inhibitor, inhibits IB ubiquitination with IC50 ~5. 2 M without affecting proteasome activity. It blocks LPS induced expression of inflammatory cytokines in human myelomonocytic cells. It suppresses antigen induced NFB expression, inflammation and mucus production in airways of OVA sensitized mice. Product information CAS Number: 916232 21 8 Molecular Weight: 466. 46 Formula: C28H19FN2O4 Chemical