XAV939 - Wnt Antagonist. CAS# 284028-89-3 075 Slapšyte G
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XAV939 - Wnt Antagonist. CAS# 284028-89-3 075 Slapšyte GXAV939, CAS No. 284028 89 3, is a potent and selective Wnt pathway antagonist. It functions to stabilize Axin by inhibiting the poly ADP ribosylating enzymes tankyrase 1 and tankyrase 2 with IC50 of 11 nM and 4 nM, respectively. It has been used to study Wnt dependent cancers. In addition, XAV939 was shown to stabilize Axin2 level in oligodendrocyte precursor cells in the spinal cord and accelerated their differentiation and myelination after hypoxic
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