TH588 - MTH1 Inhibitor. CAS# 1609960-31-7 stone Methyltransferase but does not block the

but does not block the closely related Activin A signaling pathway

WWL113 was used at 10 µM final concentration in various in vitro assays

Carboxylesterase 3 (Ces3

CD-15-0246

selective and cell permeable inhibitor of Jumonji domain-containing protein 2 (JMJD2) histone demethylase with IC50 ~0

TH588 - MTH1 Inhibitor. CAS# 1609960-31-7 stone Methyltransferase but does not block theTH588, CAS No. 1609960 31 7, is a novel potent, selective and cell permeable inhibitor of the nudix hydrolase family MTH1 protein with an IC50 of ~5 nM. Protein co crystal structures demonstrate that TH588 binds in the active site of MTH1. It has excellent selectivity over other nudix family proteins and kinases present in the selectivity panel. The MTH1 protein sanitizes oxidized dNTP pools to prevent incorporation of damaged bases during DNA