FRAX597 Catalog No.:M9936-10 Formula: C30H28N2O6S

Formula: C30H28N2O6S

11-dimethyl-6

3]oxazol-7-yl]-3

Focus on "Divergent CFTR orthologs respond differently to the channel inhibitors CFTRinh-172

is an aminophenylthiazole that inhibits transient TMEM16A-mediated chloride currents with an IC50 value of ~1 µM

FRAX597 Catalog No.:M9936-10 Formula: C30H28N2O6SFRAX597 is a potent and selective inhibitor of the p21 activated kinases. FRAX597 inhibits tumorigenesis of neurofibromatosis type 2 (NF2) associated Schwannomas. FRAX597 inhibits the proliferation of NF2 deficient schwannoma cells in culture and displayed potent anti tumor activity in vivo, impairing schwannoma development in an orthotopic model of NF2. These studies identify a novel class of orally available ATP competitive Group I PAK inhibitors