KYA1797K - Wnt/β-catenin Inhibitor. CAS# 1956356-56-1 60077 InChi: InChI=1S/C39H65N5O8/c1-12-25(6)34(43(9)38(48)33(24(4)5)42-37(47)32(40-8)23(2)3)30(51-10)22-31(45)44-20-16-19-29(44)35(52-11)26(7)36(46)41-28(39(49)50)21-27-17-14-13-15-18-27/h13-15

InChi: InChI=1S/C39H65N5O8/c1-12-25(6)34(43(9)38(48)33(24(4)5)42-37(47)32(40-8)23(2)3)30(51-10)22-31(45)44-20-16-19-29(44)35(52-11)26(7)36(46)41-28(39(49)50)21-27-17-14-13-15-18-27/h13-15

3 μM for KDM4B

InChi: InChI=1S/C17H15NO3/c19-15-11-16(18-7-9-20-10-8-18)21-17-13-4-2-1-3-12(13)5-6-14(15)17/h1-6

InChiKey: INVTYAOGFAGBOE-UHFFFAOYSA-N

and has > 50-fold selectivity against other protein kinases

KYA1797K - Wnt/β-catenin Inhibitor. CAS# 1956356-56-1 60077 InChi: InChI=1S/C39H65N5O8/c1-12-25(6)34(43(9)38(48)33(24(4)5)42-37(47)32(40-8)23(2)3)30(51-10)22-31(45)44-20-16-19-29(44)35(52-11)26(7)36(46)41-28(39(49)50)21-27-17-14-13-15-18-27/h13-15KYA1797K, CAS No. 1956356 56 1, is a highly potent and selective Wnt catenin inhibitor with IC50 ~0. 75 M (TOPflash assay). It binds directly to the regulators of G protein signaling domain of axin, initiating catenin and Ras degradation through enhancement of the catenin destruction complex activating GSK3. KYA1797K can effectively suppress the growth of CRCs harboring APC and KRAS mutations, as shown by various in vitro studies and by in vivo