Idasanutlin Size:10mg solid 38(5):309-313

38(5):309-313

6(10):1021-8

CL-387785 covalently bound to EGF-R

8 µM and inhibited fatty acid synthesis in primary rat hepatocytes with an IC50 of 3

Smiles: O=C(/C=C\N1C=NC(=N1)C1C=C(C=C(C=1)C(F)(F)F)C(F)(F)F)NNC1=CN=CC=N1

Idasanutlin Size:10mg solid 38(5):309-313Idasanutlin, also known as RG7388 and RO5503781, is a highly potent and selective MDM2 antagonist with potential anticancer activity. RG7388 binds to MDM2 blocking the interaction between the MDM2 protein and the transcriptional activation domain of the tumor suppressor protein p53. By preventing the MDM2 p53 interaction, p53 is not enzymatically degraded and the transcriptional activity of p53 is restored. This may lead to p53 mediated induction of