VLX1570 - CAS# 1431280-51-1 size:10mg solid InChi: InChI=1S/C26H33NO2/c1-19(11-16-24-21(3)10-7-17-26(24

InChi: InChI=1S/C26H33NO2/c1-19(11-16-24-21(3)10-7-17-26(24

Nifedipine and AP-3 on primary cultures of cerebellar granule cells in an oxygen-glucose deprivation model

NAALADase inhibitor

Smiles: CC(C)(C)OC(=O)C1=CN=C(C=C1)N1NC=C(C1=O)N1C=CN=N1

is effective in shrinking tumors in both C/L858R and C/L+T mice

VLX1570 - CAS# 1431280-51-1 size:10mg solid InChi: InChI=1S/C26H33NO2/c1-19(11-16-24-21(3)10-7-17-26(24VLX1570, CAS No. 1431280 51 1, is an inhibitor of the 19S proteasome specific deubiquitylating enzymes (DUBs) USP14 and UCHL5, with apoptosis inducing and antineoplastic activities. Upon administration, VLX1570 specifically binds to both USP14 and UCHL5, thereby blocking their deubiquitylating activity. This blocks the ubiquitin proteasome degradation pathway, prevents the degradation of defective proteins, and leads to an accumulation of poly