Bleomycin sulfate - CAS# 9041-93-4 0135 It inhibits HDAC1 and HDAC3

It inhibits HDAC1 and HDAC3 with IC50 of 0

BAP1 and proteasome activity

The nuclear receptors REV-ERB-α and REV-ERB-β play an integral role in regulating the expression of core clock proteins

412:211-221

57(14):5975-85

Bleomycin sulfate - CAS# 9041-93-4 0135 It inhibits HDAC1 and HDAC3Bleomycin sulfate, CAS No. 9041 93 4, is a mixture of the sulfate salts of basic glycopeptide antineoplastic antibiotics isolated from Streptomyces verticillus. Bleomycin sulfate forms complexes with iron that reduce molecular oxygen to superoxide and hydroxyl radicals which cause single and double stranded breaks in DNA; these reactive oxygen species also induce lipid peroxidation, carbohydrate oxidation, and alterations in prostaglandin synthesis