RS-127445 - CAS# 199864-87-4 Catalog No.:M6600-2S InChiKey: RDALZZCKQFLGJP-UHFFFAOYSA-N

InChiKey: RDALZZCKQFLGJP-UHFFFAOYSA-N

HCQ altered the levels of the mTORC1 activation marker phospho-S6 and that this effect was mediated by a different mechanism than that observed for the mTOR inhibitor RAD001

CH223191 potently inhibits TCDD-induced AhR-dependent transcription

Formula: C24H26N4O4

CAS Number: 950769-58-1

RS-127445 - CAS# 199864-87-4 Catalog No.:M6600-2S InChiKey: RDALZZCKQFLGJP-UHFFFAOYSA-NRS 127445, CAS No. 199864 87 4 , is a selective; high affinity; orally bioavailable serotonin 5 HT2B receptor antagonist. RS 127445 was found to have nanomolar affinity for the 5 HT2B receptor (pKi = 9. 5+ 0. 1) and 1, 000 fold selectivity for this receptor as compared to numerous other receptor and ion channel binding sites. RS 127445 potently antagonized 5 HT evoked formation of inositol phosphates (pK(B) = 9. 5+ 0. 1) and 5 HT evoked increases in