JNJ-40411813 mifugin 2-dimethyl-2H-1-benzopyran-8-yl)-3-phenyl-2-propen-1-one

2-dimethyl-2H-1-benzopyran-8-yl)-3-phenyl-2-propen-1-one

InChi: InChI=1S/C15H15NO3S/c17-14(16-18)11-20(19)15(12-7-3-1-4-8-12)13-9-5-2-6-10-13/h1-10

InChi: InChI=1S/C21H21BrN2O3/c1-27-19-9-5-17(6-10-19)21(26)24-14-12-23(13-15-24)20(25)11-4-16-2-7-18(22)8-3-16/h2-11H

Chemical Name: 1-[4-(4-{[(2R

Biochim Biophys Acta

JNJ-40411813 mifugin 2-dimethyl-2H-1-benzopyran-8-yl)-3-phenyl-2-propen-1-oneJNJ 40411813, also known as ADX71149, is a positive allosteric modulator of the mGlu2 receptor. JNJ 40411813 acts as a PAM at the cloned mGlu2 receptor: EC50 = 147 42 nmol L in a [(35)S]GTPS binding assay with human metabotropic glutamate type 2 (hmGlu2) CHO cells and EC50 = 64 29 nmol L in a Ca(2+) mobilization assay with hmGlu2 G 16 cotransfected HEK293 cells. JNJ 40411813 displaced [(3)H]JNJ 40068782 and [(3)H]JNJ 46281222 (mGlu2 receptor PAMs),