RI-1 - CAS# 415713-60-9 ihydrochloride is a highly potent and

is a highly potent and selective inhibitor of the MLL1/WDR5 interaction with an IC50 ~2

also known as S-4661 and Finibax

InChiKey: OUEODVPKPRQETQ-CHWSQXEVSA-N

CAS Number: 2070009-25-3

LNP exerts knock-down (KD) effecton macrophages and DCs and Liposome-containing DOPE shows fusogenicity

RI-1 - CAS# 415713-60-9 ihydrochloride is a highly potent andRI 1 is an irreversible inhibitor of RAD51 (IC50s = 5 30 M), a protein that is central to homologous recombination during DNA repair and is overexpressed in a wide range of human cancer cell types. RI 1 specifically reduces gene conversion in human cells while stimulating single strand annealing. RI 1 binds covalently to the surface of RAD51 protein at cysteine 319 that likely destabilizes an interface used by RAD51 monomers to oligomerize into