EPZ005687 - CAS# 1396772-26-1 lapril MDL29951 promotes Ca2+ signaling responses

MDL29951 promotes Ca2+ signaling responses and inhibition of cyclic adenosine monophosphate (cAMP) accumulation in rat oligodendrocyte precursor cells during the period of peak GPR17 abundance

or PC-3 tumor-bearing mice (6

by in vitro binding experiments

Chemical Name: 2-[4-(4-chlorophenoxy)phenyl]-1H-1

GSK-2118436A

EPZ005687 - CAS# 1396772-26-1 lapril MDL29951 promotes Ca2+ signaling responsesEPZ005687 is a potent inhibitor of EZH2 (K(i) of 24 nM). EPZ005687 has greater than 500 fold selectivity against 15 other protein methyltransferases and has 50 fold selectivity against the closely related enzyme EZH1. The compound reduces H3K27 methylation in various lymphoma cells; this translates into apoptotic cell killing in heterozygous Tyr641 or Ala677 mutant cells, with minimal effects on the proliferation of wild type cells. Product