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Some patients report that evening administration may help them sleep through initial nausea, though evidence for specific timing recommendations is limited and individual responses vary considerably

BMJ 366:l4898

However, it can cause steatorrhea, resulting in fat-soluble vitamin deficiency, and can even cause liver damage

Also, data analysis showed that the serum GLP-1 level of patients with newly diagnosed T2DM combined with CAS was significantly reduced compared with the control group