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ADX47273 - CAS# 851881-60-2 0127 Ferrostatins inhibit oxidative lipid damage

ADX47273 - CAS# 851881-60-2 0127 Ferrostatins inhibit oxidative lipid damage

Name: ADX47273 - CAS# 851881-60-2 0127 Ferrostatins inhibit oxidative lipid damage
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ADX47273 - CAS# 851881-60-2 0127 Ferrostatins inhibit oxidative lipid damageADX 47273, CAS No. 851881 60 2, is a potent and selective mGluR5 receptor PAM (positive allosteric modulator), EC50 = 0. 17 m, with no effect on other mGluR subtypes. In vivo, ADX47273 increased extracellular signal regulated kinase and cAMP responsive element binding protein phosphorylation in hippocampus and prefrontal cortex, both of which are critical for glutamate mediated signal transduction mechanisms. The mGluR (metabotropic glutamate

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Description

Ferrostatins inhibit oxidative lipid damage and cell death in diverse disease models

IOX4 was used at 10-50 µM final concentration in vitro and in cellular assays

alkaline phosphatase (ALP)

6(10):e25134

de Alwis DP

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