CI994 (Tacedinaline) - HDAC Inhibitor. CAS# 112522-64-2 0420 Smiles: [K+]

Smiles: [K+]

and rabbit liver (IC50=0

STAT3 upregulation in pituitary somatotroph adenomas induces growth hormone hypersecretion

+1/p-1/b14-9-

) demonstrates anti-tumor activity in NSCLC EGFR mutant xenograft models

CI994 (Tacedinaline) - HDAC Inhibitor. CAS# 112522-64-2 0420 Smiles: [K+]CI994 (Tacedinaline), CAS No. 112522 64 2, is a potent, selective and orally active histone deacetylase (HDAC) inhibitor. It inhibits HDAC1 (IC50 ~0. 57 M), HDAC2 (IC50 ~0. 90 M) and HDAC3 (IC50 ~1. 2 M). It does not inhibit HDAC6 and HDAC8 (IC50 >100 M). CI994 mediates G1 cell cycle arrest, inhibits proliferation, and induces apoptosis in tumor cell lines. It has also demonstrated antitumor activity in several tumor models, including the chemo