CYT387 (sulfate salt) ide II Smiles: CC(C)(C)[C@H](NC(=O)C1(F)CC1)C(=O)N1C[C@H](O)C[C@H]1C(=O)NCC1=CC=C(C=C1OCCOC1C=CC(CN2CCN(CC2)C2=CC(=NN=C2N)C2=CC=CC=C2O)=CC=1)C1SC=NC=1C
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CYT387 (sulfate salt) ide II Smiles: CC(C)(C)[C@H](NC(=O)C1(F)CC1)C(=O)N1C[C@H](O)C[C@H]1C(=O)NCC1=CC=C(C=C1OCCOC1C=CC(CN2CCN(CC2)C2=CC(=NN=C2N)C2=CC=CC=C2O)=CC=1)C1SC=NC=1CMomelotinib (CYT387, LM 1149 , CYT11387) is an ATP competitive inhibitor of JAK1 JAK2 with IC50 of 11 nM 18 nM, ~10 fold selectivity versus JAK3. Momelotinib (CYT387) induces apoptosis and autophagy. Phase 3. Product information CAS Number: 1056636 06 6 Molecular Weight: 610. 62 Formula: C23H26N6O10S2 Chemical Name: N (cyanomethyl) 4 (2 {[4 (morpholin 4 yl)phenyl]amino}pyrimidin 4 yl)benzamide; bis(sulfuric acid) Smiles:
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