Gamabufotalin Catalog No.:M8396-2 CAS Number: 190786-44-8

CAS Number: 190786-44-8

It binds to both the α4β2 and α7 subtypes

Formula: C24H24Cl2N4O4

26a-hexadecahydro-5

CADTH Canadian Drug Expert Committee Recommendation: Obeticholic Acid (Ocaliva — Intercept Pharmaceuticals Canada): Indication: Primary biliary cholangitis [Internet]

Gamabufotalin Catalog No.:M8396-2 CAS Number: 190786-44-8Gamabufotalin (Gamabufagin), a major bufadienolide of Chansu, has been used for cancer therapy due to its desirable metabolic stability and less adverse effect. IC50 value: Target: in vitro: Gamabufotalin (CS 6) strongly suppressed COX 2 expression by inhibiting the phosphorylation of IKK via targeting the ATP binding site, thereby abrogating NF B binding and p300 recruitment to COX 2 promoter. In addition, CS 6 induced apoptosis by activating the