YM 254890 60308 48(1):110-4

48(1):110-4

1080/01902148

exhibits neuroprotective effect[1]

also known as MK-0822

Afuresertib significantly increases caspase-3 and caspase-7 activities and apoptotic cell number among ACC-MESO-4 and MSTO-211H cells

YM 254890 60308 48(1):110-4G protein inhibitor. Potently inhibits Gq 11 heterotrimeric G protein signaling. Inhibits ATP UTP induced Ca2+ increase in HCAE cells expressing P2Y2 receptor (IC50 = 50 nM); carbachol induced production of IP1 in CHO cells expressing M1 receptor (IC50 = 95 nM); and ADP induced Ca2+ increase in platelets, in vitro (IC50 = 2 M). Also inhibits Gs induced cAMP elevation and G protein coupled MAPK ERK signaling. Product information CAS Number: 568580 02 9