AGN 194310 I-3 A phase I study of

A phase I study of tasisulam sodium (LY573636 sodium)

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which are not observed in PI3Kδ mutant (p110δD910A) cells

It up regulates PDX1 expression in both primary human islets and ductal cells

PHA-793887 has promising therapeutic activity against acute leukemias in vitro and in vivo

AGN 194310 I-3 A phase I study ofAGN 194310, also known as VTP 194310, is a pan antagonist of retinoic acid receptors (RARs) with Kd values of 3nM, 2nM and 5nM for RAR , RAR and RAR, respectively. AGN 194310 has been reported to bind to RARs with equal and high Kd values of 3, 2 and 5nM for RAR , RAR and RAR, respectively, by in vitro binding experiments. In addition, AGN 194310 has been revealed to potently inhibit the colony formation by ITS+ grown cell lines with IC50 values of 16